Question: Variant allele frequency with copy number
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gravatar for 9521ljh
5 months ago by
9521ljh40
9521ljh40 wrote:

the variant allele frequency(VAF) related to time-series, e.g. higher VAF related to early mutation, lower VAF related late occurred mutation.

However, if the copy number amplification with late occurred mutation, this VAF might high if mutation allele- amplified or low if wild-type allele amplified.

is there any tools to handling this kind of problem? to calculate corrected VAF?

sequencing snp • 196 views
ADD COMMENTlink written 5 months ago by 9521ljh40

I don't understand how higher VAF automatically means the mutation happened earlier. Can you explain that (or point to a paper) please?

ADD REPLYlink written 5 months ago by _r_am32k
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