Refrence datasets for imputation
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3.6 years ago
mel22 ▴ 100

Hello ! I would like to use two different datasets for genotype imoputation : 1/ 1000G data 2/ Simons foundation project data

I tried to combine both data sets but there are many different reference allels between both data sets. Could you suggest any easy way to combine them ? If not, I am using Impute5 for the imputation and it doesn't accept more than 1 refernce data set , is there any other program accepting 2 data sets other than Impute2 ( bcz it's slow and old ... )

Thank you very much !

Imputation SNP • 664 views
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Are they the same build? e.g. both build 37?

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yes both of them grch 38

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