Question: Calculating FC on probabilistic quotient normalization (PQN) data
gravatar for bridget.tripp
4 months ago by
bridget.tripp0 wrote:

I am working with publicly available metabolomics data that has been probabilistic quotient normalized (PQN). I am interested in calculating the fold changes (FC) between case/control. Some of the normalized values are negative so I am unsure if I am capturing the true differences between samples when I apply more traditional FC calculations. Is there an approach you have used to calculate fold changes on these types of normalized data?

ADD COMMENTlink modified 12 weeks ago by Biostar ♦♦ 20 • written 4 months ago by bridget.tripp0
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 2074 users visited in the last hour