Question: Is it valid to use differential gene expression analysis tool for scRNA-seq with bulk RNA-seq data?
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gravatar for tofukaj
4 weeks ago by
tofukaj10
tofukaj10 wrote:

Dear all great helpers,

As indicated by the title, I'm wondering if it is valid to use differential gene expression analysis tool for scRNA-seq with bulk RNA-seq data. I curiously tried applying MAST package with the low input RNA-seq data of my interest. It rendered me better results than those acquired from DESeq2 and EdgeR. According to my limited knowledge, I noticed some discussions about applying bulk RNA-seq DE analysis with scRNA-seq but not vice versa.

Best regards, Kaj

rna-seq • 133 views
ADD COMMENTlink written 4 weeks ago by tofukaj10
1

What does ‚better‘ mean?

ADD REPLYlink written 4 weeks ago by ATpoint40k

More significant genes acquired.

ADD REPLYlink written 4 weeks ago by tofukaj10
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