What are advantages to use globaltest, ORA and GSVA algorithms using different enrichment methods

Question

[SupBioInformatics]

Hi,

I know there are lots of experts on biostars. I know ORA needs to know total numbers of genome and not good for small sample size. globaltest uses random effect model and GSVA implements non-parametric KS test like GSEA.

I wonder if anyone can explain (simply) the differences among ORA, globaltestand GSVA algorithms for gene enrichment analysis. Or what are the advantages for different enrichment analysis to explain to others?

Thank you.