I am analyzing expression microarrays data and after reading
CEL files I perform RMA in order to get background corrected, normalized and summarized data. I have seen that some people transform this corrected data to zscore in order to reduce noise between samples. So instead of performing the differencial expression analysis on the log2 expression values obtained after RMA, they perform the analysis on the zscore of these log2 values.
Could anybody explain if this processing makes sense?