SV calling with duplication amplification
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Entering edit mode
5 months ago
vctrm67 ▴ 20

Based on diagrams like this, it seems structural variant calling relies on detecting duplications based on if they lie in the same DNA strand. Can SV callers detect local duplications if the duplication is off the strand (ie. free-floating), like cytosolic focal amplifications? In this case the reads would not have any splitting when mapped to the reference.

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