Intro: A joint position is available within the laboratory for Cell, Tissue and Organ engineering www.bourginelab.com) led by Paul Bourgine and the laboratory for Human Neural Development (https://www.wcmm.lu.se/research/wcmm-researchers and https://in.ku.dk/research/agnete-kirkeby/) led by Agnete Kirkeby. The Bourgine group is specialized in the generation of miniaturized bone organs recapitulating the bone and blood functions in human. The lab aims at compiling human-specific knowledge on tissue establishment towards developing innovative regenerative therapies. The Kirkeby group studies human brain development and neural subtype specification using stem cells. The group applies this knowledge for developing novel cell therapies as treatment for neurodegenerative diseases (e.g. Parkinson’s Disease, Narcolepsy). As such, both laboratories target the understanding of cellular heterogeneity in engineered stem cell-derived tissues, for both fundamental and translational applications.
Your position: The candidate will perform bioinformatic single cell RNAseq analysis from developing human skeletal and neural cells. The projects will involve the development and integration of several algorithms (e.g. SCENIC, SPRING, Pseudotime, RNA velocity) towards studying cell/tissue subtype specification, lineage trajectories, cell differentiation/maturation. Integration of genomics, proteomics and spatial transcriptomics data will also be considered. If interested, the candidate may have the opportunity to be involved in the ex vivo fabrication of human tissues/organs.
Your profile: You will be part of a friendly but highly competitive/innovative environment. We are thus seeking for a candidate with a high but healthy ambition to discover! We privilege applicants possessing a PhD degree in bioinformatics, data analytics or equivalent, and have experience with single cell RNAseq. We also consider non-PhD holders, if robust experience in single cell transcriptomics is demonstrated. You are interested in developing new algorithms and integrate those for the interpretation of complex datasets. The capacity to interpret, connect and visualize complex data is desired. Background in skeletal/brain development, stem cells or hematopoiesis is a plus. Excellent speaking/writing English level is a requirement.
The institute: You will be part of the Wallenberg Center in Molecular Medicine and the Stem Cell Center within Lund University (Sweden). You will benefit of state-of-the-art services/equipment and be most welcome in a young, friendly and dynamic environment. The university founded in 1666 is the first Swedish University and is repeatedly ranked among the world’s top 100 universities. With a direct connection to Copenhagen International airport (30min), Lund is an accessible city and a European hub for research.
Application / Contact: Candidates should send a CV, a short summary of research experience, and contact information for referees to: email@example.com and firstname.lastname@example.org
Supporting publications: -https://www.nature.com/articles/s41587-020-0525-0?draft=collection -https://www.nature.com/articles/s41467-020-16225-5 - https://www.cell.com/iscience/pdf/S2589-0042(19)30284-6.pdf - https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30044-7