Question: PLINK beta coefficient
gravatar for seta
9 weeks ago by
seta1.4k wrote:

Dear all,

I analyze the genetic variation association with a given quantitative trait using PLINK. As I found, this tool reported a beta coefficient per one minor risk allele; so, this value (beta) will be multiplied in 2 for the individuals with two minor risk alleles, yes? However, the beta value of two risk alleles can not be exactly two-fold of one risk allele even under the additive model, isn't it?

Any comments would be highly appreciated

ADD COMMENTlink written 9 weeks ago by seta1.4k
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