Question: PLINK beta coefficient

0

seta •

**1.4k**wrote:Dear all,

I analyze the genetic variation association with a given quantitative trait using PLINK. As I found, this tool reported a beta coefficient per one minor risk allele; so, this value (beta) will be multiplied in 2 for the individuals with two minor risk alleles, yes? However, the beta value of two risk alleles can not be exactly two-fold of one risk allele even under the additive model, isn't it?

Any comments would be highly appreciated