Hi guys, it's quite urgent and I really hope someone can help me out by explaining this to me TT. If we want to use human coronaviruses to do some bioinformatics analysis, it will be the best to retrieve sequences/genomes from human host? Or it doesn't matter?
This is because I got the deposited data file of all human coronaviruses sequences from a published article from PNAS, and I realised small number of the sequences retrieved are not from human host or they are from unknown host. I am confused whether human coronaviruses genomes/sequences must be from human host or other animal host should be okay too. Can any experts/professionals or anyone who are familiar with this, explain to me about this matter?
By the way, when I'm downloading the sequences and sequences information from NCBI database, I managed to check the host of that particular sequence/genome. That's why i found out there are human coronavirus sequences from animal host.
p/s: Sorry if the question sounds a bit stupid, but I'm very new in this thing :'D
Thank you in advanced for all the explanations and I really appreciate it :)