I have downloaded GnomAD vcf file and want to calculate the minor allele frequency of each variant in that file. But I am not quite sure how to do that. I have an INFO column which has AC,AF, AN in there. Does AF refers to minor allele frequency for that variant? If not then how can I calculate the minor allele frequency. I've given below three variants from the file just to show you what a gnomAD file looks like
chr1 905315 . C A 293.0 PASS AC=1;AN=143276;AF=6.97954e-06;variant_type=snv... chr1 905311 906011 chr1:905311-906011 63 . 905431 905432 0,0,0 2 70,528 0,172
chr1 905315 rs1489213119 C T 1432.0 PASS AC=1;AN=143276;AF=6.97954e-06;variant_type=snv... chr1 905311 906011 chr1:905311-906011 63 . 905431 905432 0,0,0 2 70,528 0,172
I am sorry if this is a basic question. I am new to bioinformatics and haven't been able to find a solution yet.