What is isogenic replicate in ENCODE project
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11 months ago
progistar ▴ 20

Hello,

I have a quick question about "isogenic replicate" in ENCODE project.
In my best knowledge, the term "isogenic replicate" means genetically modified sample compared to that of control.
However, in ENCODE project, the term does not mean what I think because they do not mention "what kind of modification they use" (but I'm not sure...).
Anyone knows about the term? If then, please post it!

Thanks!

ENCODE • 792 views
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Entering edit mode
11 months ago
ATpoint 55k

https://www.encodeproject.org/data-standards/terms/

Isogenic replication – Biological replication. Two replicates from biosamples derived from the same human donor or model organism strain. These biosamples have been treated separately (i.e. two growths, two separate knockdowns, or two different excisions).

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I misunderstood the meaning of "two growths" when I saw ENCODE term page.
Surprisingly, I can suddenly understand the meaning from your post. lol!!
Thanks for your post!!

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