Question: Where Can I Find These Data?
2
gravatar for atoogoe
7.7 years ago by
atoogoe30
United States
atoogoe30 wrote:

Folks!

Where can I find public repositories that contain good data for each of the following?

  1. SNP-alleles to gene-expression
  2. gene-expression to protein-levels

Your help would be very much appreciated. Thanks.

-Ato

gene allele protein snp • 1.5k views
ADD COMMENTlink modified 3.7 years ago by Biostar ♦♦ 20 • written 7.7 years ago by atoogoe30

I've recently become very interested in the correlation between RNA levels and protein activation (indeed, there doesn't seem to be any), and found some evidence for a low correlation (R<0.4) for any given RNA~protein association - but this review looked at 10 studies (4 cell lines, 6 human in-vivo studies) of specific genes. If there is indeed a database on the expected/observed relationship between RNA and protein, that would be a very valuable resource.

ADD REPLYlink written 7.7 years ago by Luke40

Hi luke,

Can you provide a link or title of the review you mentioned in your comment? Thanks

ADD REPLYlink written 7.7 years ago by atoogoe30

Hello. The review I am referencing is unpublished (although the author, Nancy Kendrick, does intend on publishing shortly). http://www.kendricklabs.com/WP1_mRNAvsProtein.pdf

ADD REPLYlink written 7.7 years ago by Luke40

Thanks for sharing, Luke.

ADD REPLYlink written 7.7 years ago by atoogoe30
3
gravatar for ff.cc.cc
7.7 years ago by
ff.cc.cc1.3k
European Union
ff.cc.cc1.3k wrote:

I suppose you refer to eQtl database in point 1), if so this post is a good starting point.

Summary:

1) Pritchard lab at Chicago

2) GTEX at NCBI

3) Genevar

4) SCAN DB

Sorry, but I'm not aware of repository about 2)

ADD COMMENTlink written 7.7 years ago by ff.cc.cc1.3k

Eternal gratitude!

ADD REPLYlink written 7.7 years ago by atoogoe30
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