Question: Coding Sequence Mutation Rate
1
gravatar for Davy
8.5 years ago by
Davy370
United States
Davy370 wrote:

I'm looking for some record of how the the mutation rate of a gene (probability of mutation occurring at any coding base within that gene) is modified based on the gc content of the gene.

So as an example let's say the genome wide mutation rate is 1.1 x 10^-8 (according to http://www.ncbi.nlm.nih.gov/pubmed/22345605 ), and the coding length of gene A is 4000 bp, with a gc content of 68%.

Then in theory the probability that gene A containing a mutation is 1.1x10^-8 * 4000. I want to know how this probability is modified by the gc content. Is it lower, is it higher, if so, by how much. or does it change at all?

Cheers, Davy

gc dna • 1.8k views
ADD COMMENTlink modified 8.5 years ago by Rm8.0k • written 8.5 years ago by Davy370
1
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1522 users visited in the last hour
_