Are there any alternatives to the DrugBank database for drug-gene targets with downloadable content or a software library in Python or R?
Naming a couple, the best choice might depend on your use case (e.g. market data information, level of association, types of chemicals):
They have a working API. They also have some support in Bioservices library - https://github.com/cokelaer/bioservices.
Comparative Toxicogenomics Database
http://ctdbase.org (associations can be downloaded in a single batch).
Supertarget and/or SuperDRUG2
Finally a link to an entry in BiOkeanos, in case you want to look for other similar databases:
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