TCGA methylation data analysis. beta values to differentially regulated CpGs
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8 months ago

To obtain differentially methylated points when starting from un normalized TCGA methylation beta values hosted at eg Xena browser, is there a need to normalize data before differential analysis? This is what I think is the usual practice as recommended in different BioC methylation analysis pipelines. I do not understand why one should normalize beta values. Are not these values already comparable between different arrays and different in this regard to eg expression values in microarrays?

methylation beta values DMP • 312 views

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