How to Interpret Author's Methods in this article?
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7 weeks ago

I have to reproduce a result for school reasons (bioinformatics exam) and I was assigned a certain article. In particular I have to reproduce what some authors did in: doi: 10.1371 / journal.pone.0217889. From what I understand, they make functional enrichments in respect of three variants of protein disorder. They consider vectors whose components are proteins (belonging to a certain type of disorder flavour) in a functional class divided by the total number of proteins in that functional variant. The problem is that if I go for an enrichment in GO terms for a certain set of proteins, the same GO terms do not necessarily come out for another set of proteins. So my question is: in relation to the paragraph 'Clustering of the variants of disorder through functional profiles' how do I construct the vectors that they then use in clustering?

Thanks in advance

The full quote to the article is Deiana A, Forcelloni S, Porrello A, Giansanti A. Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell. PLoS One. 2019; 14 (8): e0217889. Published 2019 Aug 19. doi: 10.1371 / journal.pone.0217889

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