I have a simple request: lets say we have 4 proteins. I know from several databases (Stitch, Uniprot, Etc..) that protein A binds directly to 3 different proteins (B, C, D), with experimental evidences.
If protein A has point mutation(s) or INDEL at known position(s), is there a way to predict its impact (Yes/No) on interaction with the other proteins. I am not interested in the function itself, but just the interaction (and maybe the stability of protein A)
Eg. In protein A, G aa replaced by Y aa at position 235 -> protein A cannot bind anymore to protein B, but can still bind proteins C and D.
Ideally I need to implement that locally because I have several proteins to test... (up to 100)
I have the feeling this is a trivial request that should have been already addressed, but I cannot find any hints in the web.
Could you give me some recommendations/papers/links/database where I could start first (instead of reinventing the wheel ahah)
Thank you very much