Forum:What Are The Most Influential Bioinformatics/Computational Biology Papers Of 2020?

Question

[Raony Guimarães]

What Are The Most Influential Bioinformatics/Computational Biology Papers/Methods/Discovery Of 2020?

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Answer 1

[Joe]

I don't think any 2020 thread is complete without the AlphaFold paper (hype aside):

https://www.nature.com/articles/s41586-019-1923-7

Answer 2

[ATpoint]

Probably the scvelo paper should be mentioned. I am not sure to what extend people really productively use the concept of RNA velocity to make biological findings, but without a doubt prominent in discussions and fora. At least there are a large number of issues at their Github, plus Bioconductor wrapped it into an R interface via the velociraptor package, I guess that qualifies as influential.

https://www.nature.com/articles/s41587-020-0591-3

Answer 3

[Gjain]

Even though it is a controversial topic among many of my colleagues I liked this paper

Hou, W., Ji, Z., Ji, H., & Hicks, S. C. (2020). A systematic evaluation of single-cell RNA-sequencing imputation methods. Genome biology, 21(1), 1-30.

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02132-x

Answer 4

[Mensur Dlakic]

This issue is far from settled, but definitely a step in the right direction.

A complete domain-to-species taxonomy for Bacteria and Archaea

• https://www.nature.com/articles/s41587-020-0501-8