mutation analysis, somatic alteration, gene

Question

[Rob]

Hi people, I want to perform mutation analysis for comparison between two groups. I downloaded mutation file of TCGA. I dont know how to do this analysis and what we need to compare ? what kinda test needs to be used? what is the workflow?

I assumed these three columns in mutation file can be importan but I am not sure which one I need to use:

VARIANT_CLASS
Variant_Classification
Variant_Type

anyone has instruction? Thanks