I have questions which wish your help.
I read paper about exome sequencing and found that in cancer sequencing, there were very few papers. I do not know what are your opinions about Solid sequencing, is it not good or having some problems?
Besides, when using chip to capture exome regions, how about 1 chip corresponds to 4 samples? Is there any problems?
From my own experience and empirical observation most (if not all) bioinformaticians seem to try to avoid working with the SOLiD sequencing platform because it produces data in color space format and that precludes them from using the majority of existing tools and techniques. This can be very frustrating.
The second part of your question has to do with barcoding the samples, the only question that needs to be determined is the coverage of the samples for each barcode. As long as you get sufficient coverage you can add as many samples as the platform supports.