How will the fusion sequence looks like in RNA level

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3.1 years ago

sichen0415 • 0

Hi, This is from the cosmic data base. And will these two be the same sequence in RNA level even they have different break point in the intron.

fusionID ENST_left Gene_left breakpoint_left ENST_right Gene_right breakpint_right

2278 ENST00000396373.4 ETV6 1_1283+6173 ENST00000300305.3 RUNX1 504-45617_6222

2279 ENST00000396373.4 ETV6 1_1283+10675 ENST00000300305.3 RUNX1 504-22599_6222

And to be further, what about the insGGUG, will that show in RNA level?

fusionID ENST_left Gene_left breakpoint_left ENST_right Gene_right breakpint_right

469 ENST00000269122.3 CLTC 1_5101_insGGUG ENST00000389048.3 ALK 4080-120_6220

470 ENST00000269122.3 CLTC 1_5101 ENST00000389048.3 ALK 4080-120_6220

Thanks a lot for the help.

rna-seq next-gen • 457 views

ADD COMMENT • link 3.1 years ago by sichen0415 • 0

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Hi,

Yes, if the break points of both fusions are in the same intron they should be the same sequence in RNA level.

ADD REPLY • link 3.1 years ago by desouzareis.r ▴ 280

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