Is there anyone who knows if the SIFT or Polyphen-2 can be used to analyse the SNPs from pig genome?? Please I want your suggestions. I have made some changes in the uniprot files in Polyphen-2 to get the pig annotations and files but I am not sure if it gives me correct results. is there any other way to do this?
How to decide which SNPs are damaging if we get a bit different results from SIFT and Polyphen? Should I consider the overlapping set between SIFT and polyphen?