Mutated Gene Sequence Database For Breast Cancer
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10.3 years ago
Elena ▴ 240

Is there any database to get the mutated gene sequence responsible for breast cancer or we have to generate our own mutated sequence using SNP database?

snp database cancer sequence search • 7.0k views
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What do you really mean ? You want a repository of known mutations that cause breast cancer ? Which genes are you interested in ? Precise and clarify your question so that people can try to help you.

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i need mutated breast cancer genes for my analysis.. so i m bit confused whether there is an existing database which consists of sequences having mutations in it.

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10.3 years ago

The COSMIC database may have what you're looking for.

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Ya... but the cosmic database is limited to only few genes, it doesn't contain information for many other genes like BCAR3, MAP3K1, BRMS1 and more.

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Ya... but the cosmic database is limited to only few genes, it doesn't contain information for many other genes like BCAR3, MAP3K1, BRMS1, NCOA3 and many more..

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There seems to be an enormous list of genes at that link, unless I'm reading it incorrectly. The top of the page just shows the "top 5".

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It has information on these genes, e.g. http://www.sanger.ac.uk/perl/genetics/CGP/cosmic?action=byhist&s=4&hn=carcinoma&sn=breast&ln=BCAR3 -- but it was not found to be mutated in the samples they have

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ya the gene names are present, but the mutations on these genes are not present...

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10.3 years ago
User 59 13k

You might however be interested in BIC "An Open Access On-Line Breast Cancer Mutation Data Base" although 'open' will still require you to register.

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10.3 years ago
Neilfws 49k

As others have pointed out, there is no single "mutated gene sequence responsible for breast cancer".

If you're looking for SNPs that increase susceptibility to the disease, a good starting point is OMIM. You can search with a simple term (e.g. "breast cancer") to get started. Then, click on the tab that says "OMIM dbSNP" to limit results to those loci with a known SNP. View a gene from the list of results and you'll see a "SNP" link in the links box on the right of the page, which will take you to dbSNP entries - e.g. this page for BRCA1.

You can also do all of this programmatically, but I'd learn the basics of how the website works first.

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I want to know the known mutations in the particular gene which influences the risk of cancer.

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10.3 years ago
Mary 11k

Try the International Cancer Genome Consortium site. The data is new and still flowing in, but worth checking. The data portal is http://dcc.icgc.org/ , but for a grasp of the whole project see the main site: http://icgc.org/

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10.3 years ago
toni ★ 2.2k

'...mutated gene sequence responsible for breast cancer...'

that simply doesn't exist. So there is also no database.

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okay... so i need to do modify the normal sequence into mutated one..thank you.

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9.0 years ago
jvijai ★ 1.2k

Your HolyGrail is hosted by NHGRI here http://research.nhgri.nih.gov/projects/bic/

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