Hi, can anybody point me to the oldest (or maybe, seminal?) bioinformatics paper? A search of Pubmed gives me a paper from the early 90's but surely there's stuff older than that. Any pointers would be appreciated.

An update based on some comments below: I realized that the answers to this question depends on agreeing what bioinformatics is. Clearly, there are many ways to define the field; what I was hoping to find are the foundational papers (or regarded as such) that initiated core techniques in bioinformatics. Even then I realize it's an open ended question - so if nothing else, I'm happy to get subjective views of bioinformatics 'lore'

Somehow related to What Are The Classic Papers In Bioinformatics?

Indeed, just came across this. I was hoping that there would a (or a few) founding papers that are regarded as the starting point for the field. DB Searls paper provides a nice history

If the definition of 'bioinformatics' is subjective, so is this question.