Titv Meaning

Question

[daghrach]

what are the TiTv ratio ?

[Neilfws]

Tips for future questions: 1) define technical terms (e.g. TiTv) since not everyone understands abbreviations; 2) give some indication that you have tried to find an answer yourself, rather than just asking straight away. In this case, answers appear on the first page of a Google search.

Answer 1

[Irsan]

Transitions (Ti) are single nucleotide variations where

A <-----> G

C <-----> T

Transversions are single nucleotide variations where

A <-----> C

A <-----> T

G <-----> C

G <-----> T

Typically, in single nucleotide variations detection, transitions are seen twice as much as transversions (ratio 2).

[Vivek]

I'd assume that 2:1 ratio is for whole genome analysis. For exomes the ratio is 3:1 I think.

Answer 2

[Pierre Lindenbaum]

transition transversion ratio