Question: Titv Meaning
1
gravatar for daghrach
7.0 years ago by
daghrach10
daghrach10 wrote:

what are the TiTv ratio ?

calling variant • 1.8k views
ADD COMMENTlink written 7.0 years ago by daghrach10
3

Tips for future questions: 1) define technical terms (e.g. TiTv) since not everyone understands abbreviations; 2) give some indication that you have tried to find an answer yourself, rather than just asking straight away. In this case, answers appear on the first page of a Google search.

ADD REPLYlink written 7.0 years ago by Neilfws48k
4
gravatar for Irsan
7.0 years ago by
Irsan7.0k
Amsterdam
Irsan7.0k wrote:

Transitions (Ti) are single nucleotide variations where

A <-----> G

C <-----> T

Transversions are single nucleotide variations where

A <-----> C

A <-----> T

G <-----> C

G <-----> T

Typically, in single nucleotide variations detection, transitions are seen twice as much as transversions (ratio 2).

ADD COMMENTlink modified 7.0 years ago • written 7.0 years ago by Irsan7.0k

I'd assume that 2:1 ratio is for whole genome analysis. For exomes the ratio is 3:1 I think.

ADD REPLYlink written 7.0 years ago by Vivek2.3k
1
gravatar for Pierre Lindenbaum
7.0 years ago by
France/Nantes/Institut du Thorax - INSERM UMR1087
Pierre Lindenbaum124k wrote:

transition transversion ratio

ADD COMMENTlink written 7.0 years ago by Pierre Lindenbaum124k
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