7.9 years ago by
Rochester, NY USA
I'm not sure what you plan to do with this file when you have it -- but remember when it comes to pathways in biology the bottom line is curation, curation, curation. There really isn't a good standardized naming convention for pathways and which genes that belong to them and when -- many are canonical "biochemical" pathways, or signal-transduction pathways -- and I would hazard that the membership of a gene in many/most pathways is very cell-type and context-specific (so membership is different from cell-type to cell-type during development vs adult life). I would also be cautious about assuming pathway membership in yeast would be equivalent to pathway membership in humans.
For some examples, you can get a limited set from NetPath. HPRD has a file of protein-protein interactions -- but without pathways "named" it seems, and the last release was 2010. BioGRID has their data available for download (and as a nice cytoscape plugin), but again -- the grouping genes into named pathways is up to curation.