Question: Nucleotide Repeats Associated With Cancer?
1
gravatar for Elena
8.1 years ago by
Elena240
Elena240 wrote:

Hi Friends,

Is there any repeats (short nucleotides like AT or GC or GATA repeats) which can be one of the factor for causing breast cancer? and is there any article regarding it?

repeats cancer • 1.5k views
ADD COMMENTlink modified 8.1 years ago by Bio_X2Y3.6k • written 8.1 years ago by Elena240

Could you please add some more information: Why do you think this might be the case? What part of the literature have you surveyed so far?

ADD REPLYlink written 8.1 years ago by Michael Kuhn5.0k

I have changed the title, check it out. The way you put it in the first place gave me the impression that you were asking whether repeats are the only responsible for cancer.

ADD REPLYlink written 8.1 years ago by Giovanni M Dall'Olio26k

I don't think this is necessarily bioinformatics related.

ADD REPLYlink written 8.1 years ago by Daniel Swan13k

actually it has been studied that Trinucleotide repeats affect DNA replication in vivo.

ADD REPLYlink written 8.1 years ago by Elena240

So please can you expand on the bioinformatics part of this question? Otherwise it will get closed as off topic. I still don't see how this can't be answered with a PubMed search.

ADD REPLYlink written 8.1 years ago by Daniel Swan13k

as it has been studied that few repeats like CAG polymorphism causes breast cancer. So, if we find the repeats in a particular gene more in number, it means that the gene is highly prone to the disease.

ADD REPLYlink written 8.1 years ago by Elena240
6
gravatar for Bio_X2Y
8.1 years ago by
Bio_X2Y3.6k
Ireland
Bio_X2Y3.6k wrote:

The following paper seems to be asking your question, and provides a review of known associations between short tandem repeat polymorphisms and breast cancer:

EDIT: since you don't have access to that paper, here is a simplification of its Table 1, which summarises the genes with STR polymorphisms associated with breast cancer. Use with caution - I may have introduced errors or posted incorrect URLs. Also, remember to cite the authors if you use this information.

AR (Androgen Receptor)

  • STR: (CAG)n
  • Position: Exon 1
  • References: 3, 4, 5, 6, 7, 8, 9

ER-alpha (Estrogen receptor 1)

  • STR: (GT)n
  • Position: Promoter
  • References: 10, 11, 12

E2F-4 (E2F transcription factor 4)

  • STR: (AGC)n
  • Position: Exon 7
  • References: 17

CYP19 (Cytochrome P450, family 19)

  • STR: (TTTA)n
  • Position: Intron 4
  • References: 18, 19, 20, 21

CYP11A (Cytochrome P50, family 11)

  • STR: (TAAAA)n
  • Position: Promoter
  • References: 22

IGF-1 (Insulin-like growth factor 1)

  • STR: (CA)n
  • Position: Promoter
  • References: 1, 23, 24

AIB1 (Nuclear receptor cofactor 3)

  • STR: (CAG)n
  • Position: C-terminus coding region
  • References: 25, 26, 27, 28, 29

IFNG (Interferon, gamma)

  • STR: (CA)n
  • Position: Intron 1
  • References: 30

SMYD3 (SET and MYND domain containing protein 3)

  • STR: (CCGCC)n
  • Position: Promoter
  • References: 31

ERBB-1 (Epidermal growth factor receptor)

  • STR: (CA)n
  • Position: Intron 1
  • References: 32, 33, 34
ADD COMMENTlink modified 8.1 years ago • written 8.1 years ago by Bio_X2Y3.6k
1

Thanku @Bio_X2Y for the information

ADD REPLYlink written 8.1 years ago by Elena240

ya thanks for the article..

ADD REPLYlink written 8.1 years ago by Elena240

ya thanks for the article, but unable to download it.

ADD REPLYlink written 8.1 years ago by Elena240
0
gravatar for Anuraj Nayarisseri
8.1 years ago by
Indore
Anuraj Nayarisseri740 wrote:

Access dbSNP and Study the all the snps of BRCA1 gene which is associated with Breast Cancer.

ADD COMMENTlink written 8.1 years ago by Anuraj Nayarisseri740
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