Whilst considering the answer to a recent question about polymorphism definition across databases it occurred to me that I do not know how genotyping techniques can determine a polymorphism or inherited variation from a somatic mutation. I do not know if it is possible to distinguish an infrequent variation from a somatic mutation when sequencing/genotyping sequencing an individual. The only distinction I have ever seen in variation repositories is that HGMD does not store somatic variations.
So to recap: 1)when genotyping, is it possible to distinguish an infrequent variation from a somatic mutation
2)are somatic variations handled differently by any database other than HGMD
(I have seen the related question on this website regarding polymorphism vs infrequent mutation).