Question: Does Any One Know Why And How To Calculate Tissue Specificity Score
1
gravatar for biorepine
6.8 years ago by
biorepine1.4k
Spain
biorepine1.4k wrote:

I have 200 genes and 15 tissue RNA-Seq RPKM units (15 mouse tissues). I can see which tissue has high expression compared to others. But why every one calculate tissue specificty score instead of just representing the expression units and is there any easy way to do it ?

Thanx in advance

rna-seq • 2.5k views
ADD COMMENTlink modified 5.7 years ago by Charles Warden7.3k • written 6.8 years ago by biorepine1.4k
0
gravatar for Charles Warden
5.7 years ago by
Charles Warden7.3k
Duarte, CA
Charles Warden7.3k wrote:

I don't think there is a single standard way to define tissue specificity. I would probably recommend looking at tools used to define tissue-specific expression for potential ideas.

Off the top of my head, I know that TiGER has a tissue-specificity scores (they used EST data, but you probably could modify a similar type of score for RNA-Seq):

http://bioinfo.wilmer.jhu.edu/tiger/

http://www.biomedcentral.com/1471-2105/9/271

ADD COMMENTlink written 5.7 years ago by Charles Warden7.3k
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