Forum: Greatest Achievements In Bioinformatics Other Than Human Genome
3
gravatar for Aleksandr Levchuk
6.6 years ago by
United States
Aleksandr Levchuk3.1k wrote:

What were the greatest achievements in bioinformatics other than Human Genome?

bioinformatics forum • 3.2k views
ADD COMMENTlink modified 6.6 years ago by Mary11k • written 6.6 years ago by Aleksandr Levchuk3.1k
5
gravatar for aidan-budd
6.6 years ago by
aidan-budd1.9k
Germany
aidan-budd1.9k wrote:

It all depends on what one considers an achievement, but that's clear, we all know that already.

If I want to take "achievement" as meaning "completely game-changing moment which provided huge innovation to bioinformatics and also bench-biology", then one of the major moments for me was the realisation by Karlin and Altschul that the distribution of optimal alignment scores between a query sequence and a set of unrelated database sequences is better described by the extreme value distribution, rather than a normal distribution (Karlin and Altschul, 1990, Proc Natl Acad Sci U S A, 87, 2264-8).

This has enabled us to make much more accurate estimations of how likely it is that two sequences share a common structure/function; this allows us to obtain a "new" sequence and already, after a simple analysis (e.g. carrying out a BLAST search) find another sequence that is likely to have a similar function; we might, for example, already know that it is extremely likely to be a kinase; without that insight, it might take a very long time, using "just" bench methods, to arrive at the same conclusion.

Thus, this achievement has saved huge amounts of time and money in the field of biomedical research; i.e. without this achievement we would presumably be much (much much...!) less advanced in this knowledge domain than we have become.

ADD COMMENTlink modified 6.6 years ago • written 6.6 years ago by aidan-budd1.9k
4
gravatar for Gjain
6.6 years ago by
Gjain5.3k
Munich, Germany
Gjain5.3k wrote:

I vote for second phase of Encode project

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ADD COMMENTlink written 6.6 years ago by Gjain5.3k
1

I'd agree in terms of the sheer amount of data generation. Disagree in terms of interpretation and ridiculous hyperbole of some of their findings.

ADD REPLYlink written 6.6 years ago by Dan Gaston7.1k

I agree too and its always a part of such big collaborations ...

ADD REPLYlink written 6.6 years ago by Gjain5.3k
3
gravatar for Mary
6.6 years ago by
Mary11k
Boston MA area
Mary11k wrote:

My vote is Margaret Dayhoff and Richard Ledley's work, starting with the first bioinformatics program I was able to find: COMPROTEIN http://blog.openhelix.eu/?p=1078

ADD COMMENTlink written 6.6 years ago by Mary11k
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