Total possible interactions =chr length-genomic distance. Genome wide average(gwa)= total interactions for all chromosomes at distance(s)/(L1-s + L2 -s ....+Ln -s). Intrachromosomal expected = gwa(s( distance between mid points of loci)). Intrachromosomal M*(normalised)=observed inetractions /intra expected. Intrachromosomal correlation matrix =pearson correlation(intrachr (obs/exp) locus ,interchrom locus). Interchromosomal matrix (23X23)expected=(i chr interaction/total i interactions)*(j chr interaction/total j interactions)* total interchromosomal inetractions. Interchromosomal matrix(23X23)=observed i,j interactions /expected.. interchromosomal M* = expected=(i loci interaction/total i interactions)*(j loci interaction/total j interactions)* total interchromosomal inetractions. Interchromosomal matrix=observed i,j interactions /expected.. Interchromosomal correlation matrix =pearson correlation(interchromosomal i,j values)without intra chromosomal values.. Interchromosomal averages=observed interactions b/w loci on chr pair/possible interactions b/w chromosomes (product of loci on each chr)
for multiple pairings numerator and denominatr summed.
sir these are the mathematical calculations i made for Hi-C contact map study.are these correct and please can any one enlighten me on inter chromosomal averages.Im putting it in order to verify whether the calculations are correct with respect to Lieberman data.