Question: Insilico Mutation Analysis For Amino Acid Residues
gravatar for RT
7.2 years ago by
European Union
RT340 wrote:

Hi All,

I want to mutate few selected amino acid residues in protein structure and want to insilico predict their affect on protein structure. Can anyone give me some guidelines to do this. Is it fairly simple to do this or requires lot of time and skills. I am completely naive to sturctural bioinformatics and it is not my area. But this small module of my project brought me in this.

Can someone help me Please.

Thanks, R.

protein-structure mutation • 2.3k views
ADD COMMENTlink modified 7.2 years ago by Vladimir Chupakhin520 • written 7.2 years ago by RT340
gravatar for Vladimir Chupakhin
7.2 years ago by
Toledo, Spain
Vladimir Chupakhin520 wrote:

There are many tools, take a look for example at

  • I-Mutant 2.0.6 – A Tool for Predicting Protein Stability upon
  • Mutation CUPSAT – Protein Stability Analysis Tool SNAP – Predicts
  • Effect of Mutations on Protein Function iStable: off-the-shelf predictor integration for predicting protein stability changes.

Take a look also at Google Scholar for prediction + protein + mutation keywords. Here are example articles

  • Prediction of protein stability changes for single-site mutations using support vector machines
  • Large-scale prediction of protein geometry and stability changes for arbitrary single point mutations
ADD COMMENTlink modified 7.2 years ago • written 7.2 years ago by Vladimir Chupakhin520
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