Question: Methods For Identifying If Set Of Genes Is Enriched For Protein-Protein Interactions?
2
gravatar for tulipmania
6.1 years ago by
tulipmania20
tulipmania20 wrote:

Hi,

Does anyone know of any tools and/or methods for identifying if set of genes is enriched for protein-protein interactions?

So, given a list of all "known" protein-protein interactions in a genome and a subset of genes from the genome- what is the chance that this subset has X or more protein-protein interactions than would be expected by chance alone?

ADD COMMENTlink modified 2.8 years ago by Biostar ♦♦ 20 • written 6.1 years ago by tulipmania20
3
gravatar for mlongo
6.0 years ago by
mlongo40
mlongo40 wrote:

One online tool is http://www.bioprofiling.de/.

ADD COMMENTlink written 6.0 years ago by mlongo40
3
gravatar for enunvillafer
5.9 years ago by
enunvillafer100
Cuba
enunvillafer100 wrote:

hi, you can use DAVID tool

ADD COMMENTlink written 5.9 years ago by enunvillafer100
1

I use DAVID quite a bit (http://david.abcc.ncifcrf.gov/) and find it quite effective. Not the most statistically rigorous method out there but great for exploratory analyses and hypothesis generation I think. Also allows for more than just PPI's but also Pathways, GO term enrichment, etc.

ADD REPLYlink written 5.9 years ago by Dan Gaston7.1k
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