Methods For Investigating Gene-Environment Interactions?
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11.4 years ago
Faisal ▴ 50

I am looking for material that give overview statistical methods for gene-environment interaction.

genetics interaction gene • 3.6k views
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11.4 years ago
matted 7.8k

Here are some review articles that should get you started (all in Nature Reviews Genetics because why not):

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11.4 years ago

Have a look at the work done by Anna Di Rienzo's and Graham Coop's labs, who published many papers on how geographical environmental variables have constrained the genetics of human populations. You should be able to find many interesting articles on their websites.

One work by Di RIenzo and Coop is DBCline, a database that allows to see if the distribution of the allele frequency of a given SNP is correlated with a list of environmental variable. For example, you can see if there are SNPs close to the LCT gene that are correlated for the type of Foraging. Have a look at it.


screnshot from dbcline:

enter image description here

dbcline allows to check if the allele frequency of a SNP is correlated with a geographical variable, like climate, temperature and diet.

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