Question: Snp In Tfbs And In Mirna Binding Site
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gravatar for Dataminer
7.9 years ago by
Dataminer2.6k
Netherlands
Dataminer2.6k wrote:

Could anyone put some light on SNPs in TFBS and SNPs in miRNA binding sites and their importance in gene regulation and their role in human diseases.

Note: kindly put references also.

binding transcription snp mirna • 2.6k views
ADD COMMENTlink modified 7.9 years ago by Casey Bergman17k • written 7.9 years ago by Dataminer2.6k
3
gravatar for Casey Bergman
7.9 years ago by
Casey Bergman17k
Athens, GA, USA
Casey Bergman17k wrote:

Like all regions of the genome, most SNPs in TF or miRNA binding sites are either slightly deleterious or nearly neutral, with a small fraction of positively selected SNPs. Strongly deleterious or advantageous SNPs are not observed as frequently because the are lost or go to fixation rapidly.

Check out the paper by Chen and Rajewsky on "Natural selection on human microRNA binding sites inferred from SNP data" from 2006 to learn more about how to use shifts in the SNP allele frequency spectrum to detect purifying selection on (miRNA) binding sites.

ADD COMMENTlink modified 7.9 years ago • written 7.9 years ago by Casey Bergman17k
1

This is why BioStar is so good - I check my answer to make sure spelling and such are fine and I see a response that includes a paper relevant to our research. Thanks & +1!

ADD REPLYlink written 7.9 years ago by Larry_Parnell16k
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gravatar for Larry_Parnell
7.9 years ago by
Larry_Parnell16k
Boston, MA USA
Larry_Parnell16k wrote:

You should look at the recent paper by Brest et al on IRGM and Crohn's disease. The SNP they investigated alters a microRNA binding site and augments the inflamed state of this disease.

ADD COMMENTlink written 7.9 years ago by Larry_Parnell16k

Why not prepare a manuscript to discuss the different ideas from 'Chen' and 'Brest'?

ADD REPLYlink modified 5 days ago • written 5 days ago by Shicheng Guo7.4k
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