How To Get Related Kinase Family Members, Given A Kinase?

Question

[Rajarshi Guha]

Hi, I'm familiar with the kinome tree from the Manning et al paper and I'd like to be able to make use of such a tree to identify kinases that are related to a kinase of interest. As far as I can tell, the raw data to build that visualization is not available. What I'd really like is a similarity matrix of kinase sequences, from which I could run my own clustering method.

Does anybody know of a tool (or raw data that can be used) to identify kinases that are related (for varying degrees of relatedness) to a kinase of interest?

Answer 1

[Ana Rodrigues Grant]

www.kinase.com is your best bet. All the supplementary material for the Manning paper is still available there, as are updated kinase sequence files (domain and full length) for several organisms.