Question: Haplotype Blocks Identification Based On Several Snps
0
gravatar for vlata119
5.4 years ago by
vlata1190
Europe
vlata1190 wrote:

Dear all!

I'm working on the following task. Our lab guys have genotyped a couple of SNPs related to a particular disease. I need to reconstruct haplotype blocks consisting of those SNPs.

Plink software, http://pngu.mgh.harvard.edu/~purcell/plink/, seems to be an appropriate solution, but I get stucked with it. Still haven't tried other software solutions like Haploview, Beagle, etc...

Any suggestions are highly appreciated!

Mvh, vlata119

haplotype snp • 1.5k views
ADD COMMENTlink modified 5.4 years ago by anin.gregory80 • written 5.4 years ago by vlata1190

Do you have pedigree data or unrelated individuals? Where do you get stuck in plink?

ADD REPLYlink written 5.4 years ago by Zev.Kronenberg11k
0
gravatar for anin.gregory
5.4 years ago by
anin.gregory80
United States
anin.gregory80 wrote:

You should read: Jeffreys, A.J., L. Kauppi, and R. Neumann, 2001. Intensely punctated meiotic recombination in the class II region of the major histocompatibility complex. Nature Genetics 29: 217-222. This paper is foundational to your work.

ADD COMMENTlink written 5.4 years ago by anin.gregory80
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