Does Anyone Know The Difference Between Glimmer3 And Genemark2.8? | Why I Get Different Results?

Question

[jcastrofigueroa]

Hello folks

I'd like to know what is the main difference between GLIMMER3 or GeneMark2.8 to predict ORFs in unknown DNA sequences?

I have performed prediction analysis with GLIMMER3 and the result is different from the obtained with GeneMark2.8, even if I use a training data, from a very close relative.

I hope you can help.

Thanks, JFC

[Neilfws]

Difficult to answer without knowing precisely what you did.

[jcastrofigueroa]

I used GeneMark.hmm for Prokaryotes with a precomputed model for Streptomyces coelicolor. In GLIMMER I downloaded all coding sequences of DNA in S. coelicolor and I trained GLIMMER. The output was: 10 genes were found in GLIMMER and 20 genes were found in GeneMark for the same sequence query. That's what I did.