Entering edit mode
11.8 years ago
alex
▴
250
I have two groups of people, a healthy population which has carriers of disease and non-carriers and I have a sick population. I know the frequency of genetic variants in both groups. I want to know if I can say anything about the variants with any statistical certainty and how would I do that.
Variant Frequency in Healthy Population Frequency in Sick Population
X 30 25
Y 5 700
Z 600 600
Each group(Healthy and Sick) has 1000 people in it. Can I say anything about each variant?
sure. chi-square test, binomial test and many many more. Also, these numbers are not frequencies, they are counts.
Sorry, should have said counts. Thanks!
lol no worries. [R] has all the machinery for you. you can do a chi-square matrix(3*2), ref count / alt count for all groups.
What would go in the matrix?