I want to find sequence data about leukemia patients as much as possible. but I only find a few records in SRA database of NCBI, and find little information about the sample , e.g. the karytype, age et.al. Where to find more such database? thank you.
Hi I remember some 10 years ago my genetics teacher told me McKusick built a catalog of human genes and phenotypes called OMIM (Online Mendelian Inheritance in Man ) & I checked now in NCBI there is even one for animals (OMIA). Please go to NCBI website & select OMIM, type leukemia, hope u get what u want
good luck raghul
The TCGA consortium just published a study of 200 sequenced AML patients that were really comprehensively characterized (50 wgs, 150 exomes, + rnaseq + microarrays + methylation arrays, etc). Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
(full disclosure - I was heavily involved in this project)
Well a quick and dirty search using the EBI Search gives some stuff you might want to look through:
As does a search in GWAS Central:
The following sites may also be useful:
Note: due to the restrictions on the publication of patent data, some of the information you are after may be hard to find, or require you or your institute to sign a confidentiality agreement.
Another consortium (comparable to TCGA) is ICGC. I had a quick look and the also have CLL studies. As for TCGA, you (your group) needs to apply to have access to this data. Here is an overview of the datasets, they have: https://www.ebi.ac.uk/ega/dacs/EGAC00001000010.
BTW: this is only NGS data (RNA-Seq, whole genome, whole exome).