Question: Best Way To Visualize Next Generation Sequencing Tumor Evolution In A Graphic?
4
gravatar for Wayne
5.9 years ago by
Wayne1000
United States
Wayne1000 wrote:

I have a good deal of NGS data with Normal, tumor, and Relapse samples. I would like a way of graphically depicting evolution regarding different mutations and genetic events. I have data on point mutants, CNV, and fusions but no good way to represent it as an evolving tumor. Does anyone know of a figure, program, or style of graphic that would be great in vizually showing important genetic changes in tumor evolution across many samples? Any help greatly appreciated.

ngs evolution sequencing • 2.4k views
ADD COMMENTlink modified 5.9 years ago by Malachi Griffith17k • written 5.9 years ago by Wayne1000
4
gravatar for Malachi Griffith
5.9 years ago by
Washington University School of Medicine, St. Louis, USA
Malachi Griffith17k wrote:

How about something like the depiction used in Figure 2 of this paper: Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Ding et al. 2012

ADD COMMENTlink written 5.9 years ago by Malachi Griffith17k

This is beautiful.

ADD REPLYlink written 5.9 years ago by Daniel3.7k

Hello,

Do you know with which Software they did this figure ?

Thank you

ADD REPLYlink written 4.5 years ago by xenia0
1
gravatar for JC
5.9 years ago by
JC7.7k
Mexico
JC7.7k wrote:

Some previus examples only show key points suring tumor progression, such as http://www.pnas.org/content/105/11/4283/F5.large.jpg

In your case, maybe you can plot some karyograms showing coverages, duplications and marking all events as occured in time. Please share your plot ...

ADD COMMENTlink written 5.9 years ago by JC7.7k
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