Best Way To Visualize Next Generation Sequencing Tumor Evolution In A Graphic?

Question

[Wayne]

I have a good deal of NGS data with Normal, tumor, and Relapse samples. I would like a way of graphically depicting evolution regarding different mutations and genetic events. I have data on point mutants, CNV, and fusions but no good way to represent it as an evolving tumor. Does anyone know of a figure, program, or style of graphic that would be great in vizually showing important genetic changes in tumor evolution across many samples? Any help greatly appreciated.

Answer 1

[Malachi Griffith]

How about something like the depiction used in Figure 2 of this paper: Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

[Daniel]

This is beautiful.

[xenia]

Hello,

Do you know with which Software they did this figure ?

Thank you

Answer 2

[JC]

Some previus examples only show key points suring tumor progression, such as http://www.pnas.org/content/105/11/4283/F5.large.jpg

In your case, maybe you can plot some karyograms showing coverages, duplications and marking all events as occured in time. Please share your plot ...