I have a good deal of NGS data with Normal, tumor, and Relapse samples. I would like a way of graphically depicting evolution regarding different mutations and genetic events. I have data on point mutants, CNV, and fusions but no good way to represent it as an evolving tumor. Does anyone know of a figure, program, or style of graphic that would be great in vizually showing important genetic changes in tumor evolution across many samples? Any help greatly appreciated.
How about something like the depiction used in Figure 2 of this paper: Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Some previus examples only show key points suring tumor progression, such as http://www.pnas.org/content/105/11/4283/F5.large.jpg
In your case, maybe you can plot some karyograms showing coverages, duplications and marking all events as occured in time. Please share your plot ...