Conservation Of Coding And Non Coding Exons

Question

[Puthier]

Hi to everyone, I'm looking for bioinformatic papers describing the average level of conservation, across vertebrates, of both coding (part of CDS) and non coding exons (particularly those found in the 5'UTR). Thanks for help.

Answer 1

[Chris Evelo]

You could start with the recent review by Eric Lander in Nature about [?]"The initial impact of the sequencing of the human genome"[?]. The first figure (called evolutionary conservation maps) gives a nice overview of what you are asking for.

[Puthier]

Thanks Chris. I will read this article that seems very nice.