I want to get a list of regulated genes per pathway. The regulated genes are the target genes of transcription factors of a pathway and the proteins of the regulated genes are the output of the pathway. I have been searching for a dew days and I can't find such a dataset. However, there are some databases such as PAZAR that provides a dump of the TFs and genes regulated by them. My questions are
- Let's say If a TF t1 and a gene g1, one of TF t1's target genes, are on the same pathway p1, can I infer that gene g1 is regulated by a pathway p1?
- If I can't infer such a statement. How can I use the TF-target gene pair to infer a pathway that the target gene is regulated? Since each TF can have more than 1 target gene and each target gene can also be regulated by more than 1 TFs
PS. Is there any database that provide a list of regulated genes per pathway? I still hope that such data exists. I am new to this research area and trying to put the pieces of information together. Any recommendations on tutorial/online resources (for non-biologists) that I can learn more about this stuff will be appreciated too :) Thanks!