Confidence Intervals For Ors Interaction In Plink Epistasis Analysis

Question

[adolfo_ag]

Dear All

I wish to know how can i obtein the Confidence Intervals for Odds Ratio interaction (OR_INT) in epistasis analysis with PLINK.

I'd try with --ci 0.95 but is not work.

plink --file mydata --epistasis --ci 0.95

Thanks in advance!

Adolph

[zx8754]

This might be helpful: Calculate odds ratio confidence intervals from plink output?

Answer 1

[chrchang523]

For future reference, this is answered by https://groups.google.com/d/msg/plink2-users/KMB9YoZqVMQ/7AlJRmobAAAJ .

No, this isn't directly supported by PLINK 1.x (though it's a planned optional column set for PLINK 2.0 --epistasis).

For now, you can infer this from the relation between the beta/odds-ratio and the chi-square statistic:
  BETA_INT = ln(OR_INT)
  chi-square STAT = (BETA_INT / SE)^2
  -> SE = BETA_INT / sqrt(STAT)
  95% confidence interval for BETA_INT is [BETA_INT - 1.96 * SE, BETA_INT + 1.96 * SE]; exponentiate these values to get the OR_INT confidence interval