Question: Percentage Of Genome All Humans Share
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gravatar for venkateshr89
6.3 years ago by
venkateshr89710
United States
venkateshr89710 wrote:

Hi,

What is the fraction of genome that all humans share irrespective of their race/ethnicity??

I read some papers which talk about the fraction of genome shared between mouse and human but couldn't find the answer for my question.

genome gene dna • 2.9k views
ADD COMMENTlink modified 6.3 years ago by SNPsaurus50 • written 6.3 years ago by venkateshr89710
2
gravatar for Leandro Lima
6.3 years ago by
Leandro Lima930
San Francisco, CA
Leandro Lima930 wrote:

"The human nucleotide diversity is estimated to be 0.1% to 0.4% of base pairs."

http://en.wikipedia.org/wiki/Human_genetic_variation

ADD COMMENTlink written 6.3 years ago by Leandro Lima930
1
gravatar for Biomonika (Noolean)
6.3 years ago by
State College, PA, USA
Biomonika (Noolean)3.1k wrote:

This is nice review: http://onlinelibrary.wiley.com/doi/10.1111/tan.12165/full

You might want to go through this thread What are numbers every bioinformatician should know? starting from answer of Ryan Thompson for more information on this topic.

ADD COMMENTlink written 6.3 years ago by Biomonika (Noolean)3.1k
1
gravatar for SNPsaurus
6.3 years ago by
SNPsaurus50
Eugene, OR
SNPsaurus50 wrote:

There probably isn't a single nucleotide shared by all humans. Each person has >10 random mutations, so in a population of 5 billion people there are >50 billion random mutations, or at least 10X coverage of the diploid genome.

ADD COMMENTlink written 6.3 years ago by SNPsaurus50
1

I agree with SNPsaurus broadly - in some sense you need to think of the percent of the genome that x% of people share. The "no single nucleotide shared by all humans" argument is great, except that it does not allow for critical genes which are perfectly conserved because they are so important. There are bound to be some positions where any mutation is lethal.

ADD REPLYlink written 6.3 years ago by zam.iqbal.genome1.7k
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