Question: Music Path-Scan Problem
gravatar for zhouyunyun11
4.0 years ago by
zhouyunyun110 wrote:

I got the following problem from Pathscan:

Can't call method "print" on an undefined value at /usr/local/share/perl/5.14.2/Genome/Model/Tools/Music/ line 403.

Here is my input file:

genome music path-scan --bam-list ~/music/mus.hg19 --gene-covg-dir ~/music/0927_test_smg/gene_covgs/ --maf-file ~/music/pathscan_0928.maf --output-file ~/music/sm_pathways --pathway-file ~/music/downloaded_pathway/GO_101008 -bmr 1.8E-6

There shouldn't be any problem from my input file. bam-list, maf-file are all been successfully used by music bmr calc-bmr before. And the gene_covgs are the outputs from bmr calc-bmr,

the GO_101008 is downloaded from Ding-lab parsed file.

Any possible reason might cause this problem?

And also, if I set -bmr 1E-06, I got the following error:

-1.73933694703631e-14' in cdf pair 3 is not a p-val at /usr/local/share/perl/5.14.2/Genome/Model/Tools/Music/PathScan/ line 655.

Meanwhile, the most important thing: any one knows how to debug this prackage?

I know in perl, we can debug like perl -d, and watch the intermediate value from the outputs, but for music, the command line likes : Genome Music Path-scan **

Then how do I watch the intermediate value from this package?

Thanks so much for help.

Sorry, I'm very new to perl script and unix environment.

music • 1.4k views
ADD COMMENTlink modified 7 months ago by Biostar ♦♦ 20 • written 4.0 years ago by zhouyunyun110
gravatar for Cyriac Kandoth
4.0 years ago by
Cyriac Kandoth4.6k
Memorial Sloan Kettering, New York, USA
Cyriac Kandoth4.6k wrote:

The two errors you see at #403 and #655 are related. #655 is a known/unsolved error that is mentioned in the following posts: MuSIC path-scan pvalue error question about the MuSiC pathscan FDR value Genome MuSic path-scan negative p-value?

If you are familiar with Perl, you can find the code here:

Running genome music ... is the same as running perl /usr/local/bin/genome music ..., because genome is just a perl script that you can debug.

ADD COMMENTlink written 4.0 years ago by Cyriac Kandoth4.6k
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