Question: T-Test And P-Values For Microarray Expression Data
2
gravatar for khan
5.5 years ago by
khan100
Germany
khan100 wrote:

Hi all,

I have microarray expression matrix : columns are different cancers and the rows are my gene. I want to detect the artifcats in my data sets, in other word, I want to see, whether the over-under expression of genes are by chance or they have some biological reasons. How can I test this with computing P-values and T-test in R ? does anyboy knows R or bioconductor package which are specified for this task ?

ADD COMMENTlink modified 5.5 years ago by Sean Davis25k • written 5.5 years ago by khan100
2

Have you normalized your values yet? Have you looked at limma? There have been countless posts here and elsewhere on using R to analyse microarrays.

ADD REPLYlink modified 5.5 years ago • written 5.5 years ago by Devon Ryan88k
5
gravatar for Sean Davis
5.5 years ago by
Sean Davis25k
National Institutes of Health, Bethesda, MD
Sean Davis25k wrote:

It sounds like you may want to look at the limma bioconductor package. In particular, the limma user guide is an excellent resource.

ADD COMMENTlink written 5.5 years ago by Sean Davis25k
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