Are there enough existing data out there to actually do meaningful research on? Let's say I am financially secure enough to not need to work and have reasonable funds to buy/rent computational time, can I actually just mine existing datasets and publish meaningful work on arxiv? Will anyone actually take me seriously without institutional/academic backing?
There are a lot of datasets on very specific domains of research. Can we actually make them all comparable? For example, can we take chip-seq of one study and RNA-seq of another study and analyze them together? Are the biological samples taken similar enough or library prep steps well described enough to make the data comparable?