How To Normalize Loop-Designed Microarray Datasets?

Question

[biolab]

Hi everyone, I have some loop-designed microarray data. I make an example below. There are four samples: W1, W2, T1, T2.

FILE1

        W1(log2signal intensity)        W2(log2signal intensity) 
gene1   2.9                             3.9 
gene2   1.0                             2.1
...............................

FILE2

        W1(log2signal intensity)  T1(log2signal intensity) 
gene1   2.2                       2.0 
gene2   0.3                       1.1
...............................

FILE3

        W2(log2signal intensity)  T2(log2signal intensity) 
gene1   2.9                       3.9 
gene2   1.0                       2.1
...............................

FILE4

            T1(log2signal intensity)  T2(log2signal intensity) 
gene1   2.7                           2.9 
gene2   2.0                           1.0
...............................

How to normalize these four datasets and produce a combined dataset like below. THANK YOU VERY MUCH!

         W1     W2     T1   T2
gene1
gene2
...............